CURCUMIN PREVENTING INTESTINAL ISCHEMIA-REPERFUSION INJURY

Abstract INTRODUCTION Ischemia-reperfusion injury is a clinically relevant process. Several drugs have been tested to prevent or reduce its deleterious effects. Curcumin natural substance, common in many diets, known antioxidant proprieties. Our aim check capacity intestinal reperfusion injury. METHODS Four groups of six WAG/RijHsd rats (males, 240 g). Three them had 1 h clamping the superior mesenteric artery, being sacrificed 4 hours later. One these received no other treatment (control), was given 24h and 2 prior ischemia (200 mgr/kg, oral), third one alpha-Tocopherol 2h (20 ip). To assess histological four samples from distal ileon were retrieved each animal. Once embedded paraffin, sections stained with H-E blinded, assessing damage according Chiu’s scale. Results analyzed ANOVA & Dunnet’s Sidak’s multiple comparison tests. RESULTS In healthy animals, over scale ranging 0 12, damaged registered 0.92 ± 0.56. Ischemic control animals showed an index 10.14 1.43, while those receiving only reached 6.15 1.71. Animas pre-treated even lower damage: 4.05 0.62. So both treatments significantly reduced following (p < 0.0001), slightly bigger effect alpfa-Tocopherol 0.05). CONCLUSION day before reduces injury, though it does as much effective pre-treatment.